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Updated: Jul 13, 2026
07:56
Protocol for Long Duration Whole Body Hyperthermia in Mice
Published on: August 25, 2012
Methods to produce hyperthermia-induced brain dysfunction
1Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anaesthesiology and Intensive Care Medicine, Uppsala University Hospital, Uppsala University, SE-75185 Uppsala, Sweden. Sharma@surgsci.uu.se
Progress in Brain Research
|July 25, 2007
Summary
Killer heat waves cause severe illness and death. Researchers developed a new animal model to study heatstroke
Area of Science:
- Environmental Health
- Neuroscience
- Toxicology
Background:
- Increasing frequency and intensity of global heat waves pose significant health risks.
- Heat-related illnesses lead to high mortality and long-term disabilities, including neurological dysfunction.
- Current understanding of heatstroke mechanisms and effective treatments remains limited.
Purpose of the Study:
- To describe a reliable animal model for inducing hyperthermia comparable to clinical heatstroke.
- To facilitate research into the physiological effects of heat-related illnesses.
- To enable the study of central nervous system (CNS) injury during hyperthermia.
Main Methods:
- Development and description of an animal model (rats or mice) to simulate clinical hyperthermia.
- Inclusion of methods to assess key indicators of brain injury, such as blood-brain barrier (BBB) breakdown and brain edema.
- Utilizing the model to investigate systemic and organ-specific changes induced by heat stress.
Main Results:
- A validated animal model for inducing and studying clinical hyperthermia has been established.
- The model allows for comprehensive examination of heat-related effects across various organs and systems.
- Specific methods for evaluating CNS damage, including BBB integrity and edema, are detailed.
Conclusions:
- The described animal model provides a crucial tool for advancing the understanding of heatstroke pathophysiology.
- This model will aid in the development and testing of therapeutic strategies for heat-related illnesses.
- Further research using this model is essential to mitigate the growing public health threat of extreme heat events.
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01:22Methods of reducing fever
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Pharmacological Methods of Reducing Fever:
Pharmacological Methods of Reducing Fever:
01:26Thermoregulation
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