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Updated: Jul 13, 2026

An Iodide-Yellow Fluorescent Protein-Gap Junction-Intercellular Communication Assay
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Roles of gap junctions and connexins in non-neoplastic pathological processes in which cell proliferation is involved

Maria Lúcia Zaidan Dagli1, Francisco Javier Hernandez-Blazquez

  • 1Laboratory of Experimental Oncology, Department of Pathology, Faculty of Veterinary Medicine and Animal Science, University of São Paulo, Avenida Prof. Dr. Orlando Marques de Paiva 87, CEP 05508-900, São Paulo, Brazil. mlzdagli@usp.br

The Journal of Membrane Biology
|July 27, 2007
PubMed

Keywords:
Gap junction functionConnexin signalingCell proliferation mechanismsNon-neoplastic tissue repair

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Gap Junctions

The cytoplasm of adjacent animal cells can exchange small molecules, ions, and secondary messengers via the communication channels which form the gap junctions. These junctions comprise a few hundred to thousands of molecular channels, each made of two halves, called the connexon hemichannel. A connexon is a hexamer of six transmembrane connexin proteins, which assemble radially, thus forming a pore or channel in the center. One connexon hemichannel docks with a corresponding connexon on the...
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The complex three-dimensional arrangement of cells in any multicellular organism is defined and maintained by interactions of cells with each other and the extracellular matrix. Cell-cell junctions are specialized structures where the multi-protein complexes on one cell interact with the multi-protein complexes on another  cell. These cell junctions are classified  into three main types based on their function — occluding, anchoring, and gap junctions.
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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...