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Updated: Jul 13, 2026
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Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
Published on: December 17, 2010
[Hypoparathyroidism associated with autoimmune disorder].
Mika Yamauchi1, Toshitsugu Sugimoto
1Shimane University Faculty of Medicine, Internal Medicine 1, Japan.
Clinical Calcium
|July 31, 2007
Summary
Autoimmune hypoparathyroidism, characterized by reduced parathyroid hormone, can result from autoantibodies targeting the calcium-sensing receptor (CaSR). This is a common endocrine issue in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED).
Area of Science:
- Endocrinology
- Immunology
- Genetics
Context:
- Autoimmune hypoparathyroidism presents as an isolated or associated autoimmune disorder.
- Reduced parathyroid hormone (PTH) secretion is often linked to Ca-sensing receptor (CaSR) gene mutations.
- Increasing evidence suggests activating autoantibodies against CaSR also cause hypoparathyroidism.
Purpose:
- To explore the role of autoantibodies targeting the Ca-sensing receptor (CaSR) in autoimmune hypoparathyroidism.
- To investigate the prevalence and mechanisms of CaSR autoimmunity, particularly in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED).
Summary:
- Autoimmune hypoparathyroidism involves decreased PTH secretion due to autoimmune responses against the CaSR.
- APECED, also known as Autoimmune Polyendocrinopathy Syndrome type I, frequently manifests with hypoparathyroidism, likely involving CaSR epitopes.
- The precise mechanisms initiating CaSR autoimmunity and its patient population remain to be elucidated.
Impact:
- Highlights CaSR autoantibodies as a significant factor in autoimmune hypoparathyroidism.
- Underscores the importance of CaSR in APECED pathogenesis.
- Identifies knowledge gaps regarding the origins and prevalence of CaSR autoimmunity.
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