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Updated: Jul 13, 2026

State of the Art Cranial Ultrasound Imaging in Neonates
Published on: February 2, 2015
First-trimester ultrasound assessment of the nasal bone to screen for aneuploidy
Todd Rosen1, Mary E D'Alton, Lawrence D Platt
1Department of Obstetrics and Gynecology, Columbia University Medical Center, 622 West 168th Street, PH 16-66, New York, NY 10032, USA. tr2171@columbia.edu
Abstract:
Increasingly, women are choosing first-trimester risk assessment for Down syndrome and other aneuploid conditions. Recent studies have suggested that adding ultrasound assessment of the nasal bone to nuchal translucency thickness and maternal serum analytes in the first trimester will improve performance. This report assesses the current literature and discusses practical issues that must be addressed before widespread implementation of nasal bone screening in the United States.
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