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Nonlinear drift-diffusion model of gating in the fast Cl channel
1Department of Physics, University of Adelaide, Adelaide, South Australia, 5005, Australia. svaccaro@physics.adelaide.edu.au
Abstract:
The dynamics of the open or closed state region of an ion channel may be described by a probability density p(x,t) which satisfies a Fokker-Planck equation. The closed state dwell-time distribution fc(t) derived from the Fokker-Planck equation with a nonlinear diffusion coefficient D(x) proportional to exp(-gamma(x)), gamma>0 and a linear ramp potential Uc(x), is in good agreement with experimental data and it may be shown analytically that if gamma is sufficiently large, fc(t) proportional to t(-2-nu) for intermediate times, where nu=U'c/gamma approximately -0.3 for a fast Cl channel. The solution of a master equation which approximates the Fokker-Planck equation exhibits an oscillation superimposed on the power law trend and can account for an empirical rate-amplitude correlation that applies to several ion channels.
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