Related Experiment Video
Updated: Jul 13, 2026

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium
Published on: September 1, 2015
Management of cystinuria
Alexandra Rogers1, Samer Kalakish, Rahul A Desai
1Department of Urology, Mayo Clinic, Jacksonville, FL, USA.
Abstract:
Cystinuria is a monogenic disorder in which there is a transepithelial transport defect of di-basic amino acids, including cystine, ornithine, lysine, and arginine (COLA). This results in diminished reabsorption of these amino acids in both the intestine and renal proximal tubule. This article describes the disorder, reviews the mechanisms of normal COLA renal transport, and summarizes issues related to the disorder, such as the role of mutations, associated diseases, clinical manifestations, therapies, the renal impact, and handling of pediatric patients.
Related Concept Videos
Urinary Tract Calculi III: Medical Management
Urinary Tract Calculi IV: Nutrition Therapy and Prevention
Urinary Tract Calculi I: Introduction
Cystic Fibrosis: Management
Sinus disease and chronic sinusitis...
Urinary Tract Calculi V: Nursing Management
Urinary Tract Infection IV: Nursing Management
