Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Proteomics in cancer.

M A Reymond1, W Schlegel

  • 1Department of Surgery, University of Magdeburg, Germany.

Advances in Clinical Chemistry
|August 9, 2007
PubMed
Summary
This summary is machine-generated.

Proteomic studies offer potential for cancer diagnostics and therapeutics, but face challenges in data reproducibility and standardization. Overcoming these hurdles through improved study design and data integration is key to advancing cancer proteomics.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Giving patients more good days: The promise of Pessurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) for peritoneal metastasis.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2025
Same author

Technology development of hyperthermic pressurized intraperitoneal aerosol chemotherapy (hPIPAC).

Surgical endoscopy·2021
Same author

COVID-19: impact on colorectal surgery.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2020
Same author

[Not Available].

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]·2016
Same author

Quality of life of patients with end-stage peritoneal metastasis treated with Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC).

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2015
Same author

[Occupational Health Aspects of Pressurised Intraperitoneal Aerosol Chemotherapy (PIPAC): Confirmation of Harmlessness].

Zentralblatt fur Chirurgie·2014
Same journal

Cardiovascular disease and miRNA.

Advances in clinical chemistry·2026
Same journal

RNA biomarkers in antidoping.

Advances in clinical chemistry·2026
Same journal

Biomarkers for assessing magnesium status.

Advances in clinical chemistry·2026
Same journal

Advances in microfluidic extracellular vesicle technology.

Advances in clinical chemistry·2026
Same journal

Chronic low-grade inflammation in vegetarians and vegans: Biomarker evidence and methodological considerations.

Advances in clinical chemistry·2026
Same journal

Biomarkers in heart failure.

Advances in clinical chemistry·2026
See all related articles

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Proteomic studies generate valuable data for cancer diagnostics, prognostics, and therapeutics.
  • Key technologies include two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) and mass spectrometry (MS).
  • Emerging technologies like SELDI-TOF-MS, isotope-coded affinity tag technology, and various arrays offer alternative approaches.

Purpose of the Study:

  • To highlight the potential of proteomic studies in human cancer research.
  • To address the challenges hindering the confirmation and application of proteomic technologies.
  • To emphasize the need for standardized data handling and study design in cancer proteomics.

Main Methods:

  • Utilizes two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) and mass spectrometry (MS) for tissue analysis.

Related Experiment Videos

  • Employs surface-enhanced laser desorption/ionization time-of-flight (SELDI-TOF)-MS for serum/plasma analysis.
  • Considers alternative proteomic technologies such as isotope-coded affinity tag technology, reverse-phase protein arrays, and antibody microarrays.

    • Main Results:

    • Lack of overlap between studies and issues like non-uniform criteria, small patient numbers, and poor reproducibility impede technology confirmation.
    • Despite challenges, proteomic approaches show significant potential for identifying novel cancer diagnostic biomarkers.
    • Therapeutic proteomics faces complexity but promises major contributions through large-scale dataset synthesis and comparison.

    Conclusions:

    • Standardized processes for data storage and retrieval across different technologies and research groups are essential.
    • Shifting focus from technology development to study design, data organization, and mining is crucial for clinical applications.
    • Addressing reproducibility and standardization issues will unlock the full potential of cancer proteomics for clinical questions.