Cardiovascular disease and miRNA

Area of Science:

• Biochemistry
• Molecular Biology
• Cardiology

Background:

• Cardiovascular disease (CVD) presents a significant global health challenge, driving morbidity, mortality, and healthcare costs.
• Current CVD management requires improved non-invasive biomarkers for early detection and novel therapeutics for better patient outcomes.

Purpose of the Study:

• To review the molecular and clinical significance of microRNAs (miRNAs) in cardiovascular diseases (CVD).
• To explore the potential of circulating miRNAs as diagnostic and prognostic biomarkers for CVD.
• To discuss miRNAs as prospective therapeutic targets in CVD management.

Main Methods:

• Literature review of studies investigating microRNAs in cardiovascular disease.
• Analysis of research on miRNA expression profiles in conditions like stable coronary artery disease (CAD) and acute coronary syndrome (ACS).
• Synthesis of findings on the diagnostic, prognostic, and therapeutic roles of miRNAs in CVD.

Main Results:

• MicroRNA dysregulation is implicated in the pathogenesis of various CVDs.
• Specific circulating miRNAs exhibit potential as reliable biomarkers for CVD diagnosis and prognosis.
• miRNA expression profiles offer promising avenues for novel therapeutic strategies in CVD.

Conclusions:

• MicroRNAs play crucial roles in the molecular mechanisms underlying cardiovascular diseases.
• Circulating miRNAs represent a valuable resource for non-invasive CVD biomarker discovery.
• Targeting miRNAs holds significant therapeutic potential for managing and treating CVD.