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Updated: Jun 25, 2026

A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay

A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay

Published on: August 8, 2013

Biomarkers for assessing magnesium status.

Lusliany J Rondón¹, Reinaldo Marín²

¹Center for Biophysics and Biochemistry (CBB), Venezuelan Institute for Scientific Research (IVIC), Caracas, Venezuela; Biochemistry Department, School of Nutrition and Dietetics, Central University of Venezuela (UCV), Caracas, Venezuela.

Advances in Clinical Chemistry

|June 23, 2026

Summary

This summary is machine-generated.

Assessing magnesium status is challenging due to its intracellular nature. Current biomarkers are limited, necessitating the development of novel, accurate methods for detecting magnesium deficiency and guiding clinical decisions.

Keywords:

Biomarkers Clinical research Experimental research Laboratory tests Magnesium Magnesium status

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Last Updated: Jun 25, 2026

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Area of Science:

Biochemistry
Physiology
Clinical Diagnostics

Background:

Magnesium (Mg) is vital for over 600 enzymatic reactions and multiple physiological systems.
Accurate assessment of Mg status is difficult due to its intracellular distribution.
Existing methods often fail to detect subclinical magnesium deficiency.

Purpose of the Study:

To review current and novel biomarkers for assessing magnesium status.
To discuss the limitations of existing magnesium assessment methods.
To highlight the need for improved diagnostic tools for magnesium deficiency.

Main Methods:

Examination of current Mg status measures: serum/plasma, ionized Mg, urine.
Review of intracellular measurements: red blood cells, leukocytes, platelets.
Analysis of non-invasive sampling (hair, nails) and functional tests (Mg loading, balance studies).
Discussion of novel approaches: Mg Depletion Score (MDS), genetic biomarkers, pregnancy-specific applications.

Main Results:

No single biomarker reliably reflects whole-body magnesium status.
Serum Mg levels may not detect subclinical deficiency.
Combination approaches and novel biomarkers show promise for improved accuracy.

Conclusions:

Current methods for assessing magnesium status have significant limitations.
Novel biomarkers and functional tests are crucial for accurate diagnosis.
Future research should focus on developing sensitive, minimally invasive biomarkers for magnesium deficiency.