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Published on: October 28, 2022
The profile of profilins.
B M Jockusch1, K Murk, M Rothkegel
1Cell Biology, Zoological Institute, Technical University of Braunschweig, 38092 Braunschweig, Germany. bmj@tu-bs.de
Reviews of Physiology, Biochemistry and Pharmacology
|August 9, 2007
Summary
Profilins are essential eukaryotic proteins regulating actin dynamics. This review covers 30 years of research on profilin structure, expression, and diverse ligand interactions, highlighting their crucial cellular roles.
Area of Science:
- Biochemistry
- Cell Biology
Background:
- Profilins are small, highly conserved proteins found in all eukaryotes.
- They are primarily known for their role in regulating actin dynamics.
Purpose of the Study:
- To review 30 years of research on profilins since their discovery.
- To emphasize the diverse functions and interactions of profilins.
Main Methods:
- Literature review of studies on profilin structure, expression, and function.
- Analysis of profilin interactions with various cytoplasmic and nuclear ligands.
Main Results:
- Profilins interact with a wide array of ligands beyond actin.
- Tissue-specific expression of profilin isoforms contributes to their varied activities.
- Profilins play roles in both the cytoplasm and the nucleus.
Conclusions:
- Profilin's diverse ligand interactions are key to their multifaceted cellular functions.
- Understanding profilin isoforms and their tissue-specific expression is crucial for elucidating their biological significance.
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