Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...

Hemodialysis I: Introduction

Hemodialysis I: Introduction

Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...

Hemodialysis II: Procedure and Complications

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...

Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis

Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis

Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Cardionephrology: past, present and future].

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia·2014

Same author

Significance of interdialytic weight gain versus chronic volume overload: consensus opinion.

American journal of nephrology·2013

Same author

Treatment frequency and efficiency in hemodiafiltration.

Blood purification·2013

Same author

Acetate-free biofiltration reduces intradialytic hypotension: a European multicenter randomized controlled trial.

Blood purification·2013

Same author

Geographical variability of patient characteristics and treatment patterns affect outcomes for incident hemodialysis patients.

Journal of nephrology·2012

Same author

Importance of normohydration for the long-term survival of haemodialysis patients.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2012

Search research articles

Related Experiment Video

Updated: Jul 13, 2026

Three-Dimensionally Printed Microfluidic Cross-flow System for Ultrafiltration/Nanofiltration Membrane Performance Testing

Three-Dimensionally Printed Microfluidic Cross-flow System for Ultrafiltration/Nanofiltration Membrane Performance Testing

Published on: February 13, 2016

Low- (classical) and high-efficiency haemodiafiltration.

Volker Wizemann¹

¹Georg-Haas-Dialysezentrum, Giessen, Germany.

Contributions to Nephrology

|August 9, 2007

Summary

High-efficiency haemodiafiltration (HDF) may offer significant clinical advantages over conventional dialysis. Further trials are needed to confirm if high-efficiency HDF prolongs life.

Area of Science:

Nephrology
Renal Replacement Therapy

Background:

The distinction between high-efficiency and low-efficiency haemodiafiltration (HDF) is crucial due to the importance of convection volume for HDF benefits.
Experimental and observational data suggest high-efficiency HDF may offer clinical advantages over low-flux haemodialysis.

Purpose of the Study:

To evaluate the potential clinical benefits and efficacy of high-efficiency haemodiafiltration (HDF) compared to other dialysis modalities.
To highlight the need for randomized prospective trials to validate the hypotheses regarding HDF's advantages.

Main Methods:

Review of experimental and observational data concerning HDF and haemodialysis.
Discussion of the role of substitution fluid volume and extracorporeal blood flow in HDF efficacy.
Consideration of blood purification kinetics for optimizing HDF treatment protocols.

Related Experiment Videos

Last Updated: Jul 13, 2026

Three-Dimensionally Printed Microfluidic Cross-flow System for Ultrafiltration/Nanofiltration Membrane Performance Testing

Three-Dimensionally Printed Microfluidic Cross-flow System for Ultrafiltration/Nanofiltration Membrane Performance Testing

Published on: February 13, 2016

Main Results:

High-efficiency HDF, particularly with online fluid preparation, may provide significant clinical benefits and potentially prolong life compared to conventional low-flux haemodialysis.
Low-efficiency HDF demonstrates comparable convective efficacy to high-flux haemodialysis.
High extracorporeal blood flow (>500 ml/min) is safely achievable with 14-gauge needles, supporting high-efficiency HDF.

Conclusions:

High-efficiency HDF shows promise for improved patient outcomes and is potentially ideal for daily short treatments.
Further randomized controlled trials are essential to definitively establish the superiority of high-efficiency HDF.
Clinical comparisons between high-flux haemodialysis and HDF remain limited, necessitating more research.