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Related Concept Videos

Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Genomics02:02

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Ribosome Profiling02:24

Ribosome Profiling

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Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
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The technique...
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Peptide Identification Using Tandem Mass Spectrometry01:33

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Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
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The Proteasome02:18

The Proteasome

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Updated: Mar 2, 2026

Comprehensive Workflow of Mass Spectrometry-based Shotgun Proteomics of Tissue Samples
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Comprehensive Workflow of Mass Spectrometry-based Shotgun Proteomics of Tissue Samples

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Proteomics.

Visith Thongboonkerd1

  • 1Siriraj Proteomics Facility, Medical Molecular Biolo gy Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol Uni versity, Bangkok, Thailand.

Forum of Nutrition
|August 9, 2007
PubMed
Summary
This summary is machine-generated.

Proteomics offers global protein analysis for biomedical research. This technology provides valuable insights into nutrition, helping to understand metabolic pathways and identify disease biomarkers.

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Area of Science:

  • Biomedical Science
  • Nutritional Science
  • Proteomics

Background:

  • Proteomics enables high-throughput, global analysis of proteins in biological samples.
  • Protein expression is dynamic and crucial for cellular function, often not correlating directly with gene expression.
  • Advances in protein separation and mass spectrometry drive progress in proteomics.

Purpose of the Study:

  • To explore the application of proteomics in nutrition research.
  • To understand the effects of nutrients and food components on metabolic pathways.
  • To identify molecular targets and biomarkers for nutritional disorders.

Main Methods:

  • Overview of proteomics principles and technologies.
  • Summary of current protein separation techniques (gel-based and gel-free).
  • Discussion of mass spectrometry advancements in protein identification.

Main Results:

  • Proteomics provides insights into regulatory mechanisms of homeostasis during nutritional imbalance.
  • It aids in understanding the pathophysiology of nutritional disorders.
  • Proteomic analysis can identify biomarkers for diagnosis, prediction, and prognosis.

Conclusions:

  • Proteomics is a powerful tool for nutrition research, offering a global view of protein expression.
  • Systems biology, integrating multiple 'omics' data, holds significant promise for future nutrition studies.
  • This integrative approach can advance our understanding of complex nutritional interactions and health outcomes.