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Related Experiment Video

Updated: Jun 18, 2026

Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography

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Published on: April 4, 2012

Metabolic imprinting in obesity.

E L Sullivan, K L Grove

Forum of Nutrition

|December 4, 2009

Summary

Maternal nutrition during pregnancy and lactation influences offspring

Area of Science:

Metabolic programming and developmental origins of health and disease.

Background:

Obesity rates are rising in children and adults.
Metabolic imprinting establishes adult metabolic set points.
Maternal health and nutrition impact offspring's energy balance regulation.

Purpose of the Study:

To review evidence on maternal energy status and offspring obesity risk.
To explore molecular mechanisms of metabolic imprinting.

Main Methods:

Review of epidemiological studies.
Analysis of animal models.
Consideration of molecular mediators.

Main Results:

Maternal overnutrition, diabetes, and undernutrition predispose offspring to obesity.

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These maternal states result in metabolic imprinting of obesity.

Glucose, insulin, leptin, inflammatory cytokines, and epigenetics are potential mediators.

Conclusions:

Maternal nutritional status during critical perinatal periods significantly impacts offspring's long-term metabolic health and obesity risk.
Understanding these mechanisms is crucial for preventing childhood and adult obesity.