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Related Experiment Videos

Neuromodulators, not activity, control coordinated expression of ionic currents.

Olga Khorkova1, Jorge Golowasch

  • 1Federated Department of Biological Sciences, New Jersey Institute of Technology, Newark, New Jersey 07102, USA.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|August 10, 2007
PubMed
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Neuromodulatory inputs coordinate ionic current expression in neurons, maintaining stable electrical activity. Removing these inputs disrupts this coordination, but a peptide called proctolin can prevent these changes.

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Systems Neuroscience

Background:

  • Neuronal electrical activity is remarkably stable despite variable ion channel currents.
  • Coordinated regulation of ionic currents may underlie stable neuronal output.
  • The role of neuromodulation in regulating ionic current expression is not fully understood.

Purpose of the Study:

  • To investigate the role of neuromodulatory input in regulating ionic current expression in the Cancer borealis pyloric network.
  • To determine if neuromodulation controls the coordinated expression of ionic currents.
  • To explore the long-term effects of neuromodulation on neuronal intrinsic plasticity.

Main Methods:

  • Studied identified neurons in the Cancer borealis pyloric network.

Related Experiment Videos

  • Removed neuromodulatory input (decentralization) to observe effects on ionic current levels.
  • Applied the neuromodulatory peptide proctolin exogenously to assess its preventative effects.

    • Main Results:

    • Decentralization led to the loss of coordinated regulation of ionic current levels.
    • Decentralization caused significant changes in the amplitudes of several ionic currents.
    • Continuous proctolin application prevented the loss of coregulation and changes in current levels.

    Conclusions:

    • Neuromodulatory inputs play a novel, long-term role in regulating the coordinated expression of multiple voltage-gated ionic currents.
    • This coordinated regulation constrains neuronal intrinsic plasticity and network response to perturbations.
    • Loss of conductance coregulation may facilitate functional recovery in neuronal networks.