Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease and dysfunction of endothelial progenitor cells in umbilical cord blood with maternal pre-eclampsia.

Liang Xia1, Xin P Zhou, Jun H Zhu

  • 1Department of Cardiovascular Diseases, the First Affiliated Hospital, Medical School of Zhejiang University, Hangzhou, China.

The Journal of Obstetrics and Gynaecology Research
|August 11, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[A quantitative trabecular structural analysis using X-ray micro CT in ovariectomized rats].

Guang pu xue yu guang pu fen xi = Guang pu·2009
Same author

Error analysis of Cm measurement under the whole-cell patch-clamp recording.

Journal of neuroscience methods·2009
Same author

Understanding the self-assembly of charged nanoparticles at the water/oil interface.

Physical chemistry chemical physics : PCCP·2009
Same author

[Development of new SSR markers from EST of SSH cDNA libraries on rose fragrance].

Yi chuan = Hereditas·2009
Same author

Crocin and geniposide profiles and radical scavenging activity of gardenia fruits (Gardenia jasminoides Ellis) from different cultivars and at the various stages of maturation.

Fitoterapia·2009
Same author

Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation.

The Journal of clinical investigation·2009
Same journal

Elevated Body Mass Index Associated With Uterine Fibroids: A Retrospective Cohort Study With Bioinformatic Validation.

The journal of obstetrics and gynaecology research·2026
Same journal

Factors Affecting Quality of Life of Thai Cervical Cancer Patients.

The journal of obstetrics and gynaecology research·2026
Same journal

Association Between Serum Vitamin D Levels and Insulin Resistance in Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis.

The journal of obstetrics and gynaecology research·2026
Same journal

Trends in Initial Cardiac Function, Treatment, and Outcomes in Peripartum Cardiomyopathy.

The journal of obstetrics and gynaecology research·2026
Same journal

Vaginal Microbiome and Preterm Birth in Pregnant Women From India.

The journal of obstetrics and gynaecology research·2026
Same journal

Maternal Severity and Diagnostic Validity of the Revised Japanese Criteria for Obstetric Disseminated Intravascular Coagulation: A Retrospective Observational Study.

The journal of obstetrics and gynaecology research·2026
See all related articles

Pre-eclampsia is linked to lower numbers and impaired function of placental/fetal endothelial progenitor cells (EPCs). These alterations correlate with increased soluble fms-like tyrosine kinase 1 (sFlt-1) levels in umbilical cord blood.

Area of Science:

  • Obstetrics and Gynecology
  • Vascular Biology
  • Reproductive Medicine

Background:

  • Pre-eclampsia involves defective placental angiogenesis and maternal vascular dysfunction.
  • Reduced endothelial progenitor cells (EPCs) are observed in maternal circulation with pre-eclampsia.
  • EPCs are crucial for neovascularization and reendothelialization.

Purpose of the Study:

  • To investigate the presence of EPC depletion in placental/fetal circulation of pre-eclamptic pregnancies.
  • To assess the functional capacity of EPCs in pre-eclampsia.

Main Methods:

  • Collected venous cord blood from pre-eclamptic (n=14) and normotensive (n=10) mothers.
  • Enumerated circulating EPCs (AC133+/KDR+) using fluorescence-activated cell sorting (FACS).

Related Experiment Videos

  • Assessed in vitro EPC proliferation, migration, and vasculogenesis.

    • Main Results:

    • Significantly decreased circulating EPC numbers in pre-eclampsia group compared to controls (P < 0.001).
    • Reduced EPC numbers also observed after in vitro cultivation (P < 0.001).
    • Impaired proliferation, migration, and vasculogenesis capacities of EPCs from pre-eclamptic patients.

    Conclusions:

    • Documented decreased numbers and dysfunction of placental/fetal circulating EPCs in pre-eclampsia.
    • Alterations in EPCs are likely associated with elevated sFlt-1 levels in umbilical cord blood.