Neuromodulation by functional electrical stimulation (FES) of limb paralysis after stroke

Functional Electrical Stimulation (FES) in stroke patients has been demonstrated to provide clinical benefits such as improvement in movement, skills, function and decrease of spasticity. Imaging and neurophysiological studies have shown cortical excitability and reorganization. After injury, the parameters of timing, intensity, frequency, and duration of FES are still to be determined. Additional issues that should be determined are whether the changes induced by FES are long-lasting, and which clinical and electrophysiological parameters are important and to what extent.