Related Experiment Video
Updated: Jul 13, 2026
11:47
A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
Published on: June 8, 2014
[Osteonecrosis of the jaws by using bisphosphonates]
Mihály Vaszilkó1, József Barabás, György Szabó
1Semmelweis Egyetem Arc-, AlIcsont-, Szájsebészeti es Fogászati Klinika, Budapest.
Fogorvosi Szemle
|August 19, 2007
Summary
Bisphosphonate therapy, used for osteoporosis and bone tumors, can cause osteonecrosis in the jaw. Early prevention and combined surgical and antibiotic treatment are crucial for managing this side effect.
Area of Science:
- Oncology
- Orthopedics
- Dentistry
Background:
- Bisphosphonates are widely used for osteoporosis and bone defect treatment.
- Intravenous bisphosphonate therapy is associated with potential severe side effects.
Observation:
- Eight patients treated with bisphosphonates developed osteonecrosis in the maxillofacial region between September 2005 and May 2006.
- Two typical cases of bisphosphonate-induced osteonecrosis were selected for detailed review.
Findings:
- Bisphosphonate-induced osteonecrosis of the jaw is a significant concern in patients receiving this therapy.
- Early recognition and intervention are critical for managing this condition.
Implications:
- The study highlights the importance of preventive strategies in patients undergoing bisphosphonate treatment.
- A combination of surgical intervention and long-term antibiotic therapy may be effective for managing bisphosphonate-induced osteonecrosis when temporary suspension is feasible.
Related Concept Videos
01:31Osteoclasts in Bone Remodeling
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
01:40Bone Remodeling
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
01:29Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:02What is the Skeletal System?
Overview
01:31Essential Minerals for Bone Health
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
01:31Bone Remodeling and Repair
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...