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Apolipoprotein E gene polymorphism in the Mongolian population.

H Svobodová1, F Kucera, T Stulc

  • 1Third Medical Department, Charles University in Prague, 1st Faculty of Medicine, Prague, Czech Republic. svobodoh@centrum.cz

Folia Biologica
|August 21, 2007
PubMed
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The apolipoprotein E (ApoE) epsilon4 allele, linked to cardiovascular disease, is highly prevalent in the Mongolian population. This finding suggests a potential genetic susceptibility to cardiovascular conditions within this group.

Area of Science:

  • Genetics
  • Cardiovascular Disease Epidemiology
  • Human Population Studies

Background:

  • Apolipoprotein E (ApoE) is crucial for lipid metabolism, with common alleles (epsilon2, epsilon3, epsilon4) influencing its function.
  • The epsilon4 allele is associated with increased risks for cardiovascular and Alzheimer's diseases.
  • Mongolian populations exhibit high rates of cardiovascular mortality and morbidity, suggesting potential genetic factors.

Purpose of the Study:

  • To determine the frequencies of apolipoprotein E (ApoE) genotypes in a Mongolian cohort.
  • To compare these frequencies with those observed in other Asian populations.
  • To investigate the potential link between ApoE genotype distribution and cardiovascular disease susceptibility in Mongolia.

Main Methods:

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  • Apolipoprotein E (ApoE) gene sequences were amplified using polymerase chain reaction (PCR).
  • ApoE genotyping was performed using restriction enzyme digestion with CfoI.
  • Allele and genotype frequencies were calculated for 744 Mongolian subjects.

    • Main Results:

    • The relative allele frequencies in the Mongolian population were: epsilon2 (3.7%), epsilon3 (80.8%), and epsilon4 (15.5%).
    • Genotype frequencies included epsilon3/epsilon3 (65.3%), epsilon3/epsilon4 (25.4%), and epsilon4/epsilon4 (1.9%).
    • The frequency of the risk-associated epsilon4 allele in Mongolia is among the highest reported in Asian populations.

    Conclusions:

    • The high prevalence of the apolipoprotein E (ApoE) epsilon4 allele in Mongolia is notable.
    • This elevated frequency may contribute to the observed genetic susceptibility of the Mongolian population to cardiovascular diseases.
    • Further research is warranted to elucidate the specific mechanisms linking ApoE genotype to cardiovascular risk in this population.