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Related Concept Videos

Oogenesis02:07

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
Oogenesis01:22

Oogenesis

Oogenesis,  the process of developing egg cells (female gametes), occurs within the ovaries and is fundamental to female fertility. This sequence begins during fetal development when diploid oogonia in the developing ovaries undergo mitotic divisions to produce primary oocytes. By birth, these primary oocytes enter prophase I of meiosis but become arrested in this stage, remaining suspended until puberty.
Each primary oocyte is surrounded by a layer of pre-granulosa cells, forming what is known...
Menses Phase01:18

Menses Phase

The uterine cycle begins with the menstrual phase, which is considered day one of the cycle and typically lasts about five days. This phase is characterized by the degeneration and shedding of the stratum functionalis, the functional layer of the endometrium.
When fertilization does not occur, the corpus luteum deteriorates, causing a significant drop in the levels of estrogen and progesterone in the body. This hormonal decrease triggers the release of prostaglandins, which cause the uterine...
Secretory Phase01:19

Secretory Phase

The secretory phase of the menstrual cycle, spanning from day 14 to 28 in a typical 28-day cycle, is a period of significant physiological changes in the female reproductive system. This phase commences immediately after ovulation and is characterized by the preparation of the endometrium for potential embryo implantation.
Following ovulation, the corpus luteum, a temporary endocrine structure, produces progesterone and estrogens. These hormones stimulate the growth and coiling of endometrial...
Ovarian Cycle01:27

Ovarian Cycle

The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle length...
Proliferative Phase01:20

Proliferative Phase

The proliferative phase typically occurs after menstruation and lasts between 6 to 13 days in a standard 28-day cycle. This phase involves the reconstruction of the endometrium, guided by estrogen produced by the developing ovarian follicle.
Notably, the stratum basale, the basal layer of the endometrium, including the basal parts of the uterine glands, remains unaffected by menstruation. Stem cells in this layer undergo mitosis, regenerating the stratum functionalis and thickening the...

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Related Experiment Video

Updated: Jul 12, 2026

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
07:12

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice

Published on: November 24, 2020

[Pathogenesis of endometriosis].

M Nisolle1, M-L Alvarez, M Colombo

  • 1Département de gynécologie-obstétrique, université de Liège, hôpital de la Citadelle, 1, boulevard du 12(e) de Ligne, 4000 Liège, Belgique. michelle.nisolle@chrcitadelle.be

Gynecologie, Obstetrique & Fertilite
|August 24, 2007
PubMed
Summary

Endometriosis, a condition where uterine lining grows outside the uterus, causes infertility and pelvic pain. Early diagnosis and identifying molecular factors are key to developing new treatments for this estrogen-dependent disease.

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Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility

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Related Experiment Videos

Last Updated: Jul 12, 2026

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
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Mouse Model of Surgically-induced Endometriosis by Auto-transplantation of Uterine Tissue

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Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility
08:07

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility

Published on: April 5, 2024

Area of Science:

  • Gynecology
  • Cell Biology
  • Pathophysiology

Context:

  • Endometriosis is characterized by endometrial tissue outside the uterus, leading to infertility and pelvic pain.
  • Early diagnosis through gynecological history and clinical examination is crucial for effective patient management.
  • Treatment decisions involve medical or surgical options, with morbidity linked to lesion severity.

Purpose:

  • To explore the complex interactions between host tissue and endometrial cells in ectopic implantation.
  • To identify key cellular and molecular factors driving angiogenesis, lymphangiogenesis, and fibrosis in endometriosis.
  • To lay the groundwork for novel therapeutic strategies targeting endometriosis development.

Summary:

  • Endometriosis involves estrogen-dependent endometrial cell growth, angiogenesis, and lymphangiogenesis.
  • Ectopic endometrial cell implantation requires intricate host-tissue and cellular interactions.
  • Identifying factors in angiogenesis, lymphangiogenesis, and fibrosis is essential for new endometriosis therapies.

Impact:

  • Facilitates earlier and more accurate diagnosis of endometriosis.
  • Informs the development of targeted therapies for endometriosis.
  • Improves understanding of endometriosis pathogenesis for better patient outcomes.