Related Experiment Video
Updated: Jul 12, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
Published on: March 12, 2016
Health care charges for patients with ocular hypertension or primary open-angle glaucoma
Louis R Pasquale1, Margarita Dolgitser, Jeffrey N Wentzloff
1Glaucoma Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.
Insights
Patients with primary open-angle glaucoma (POAG) incurred higher healthcare costs than those with ocular hypertension (OH). Factors like age, gender, and comorbidities significantly impact these charges, highlighting the economic burden of these eye conditions.
Area of Science:
- Ophthalmology
- Health Economics
- Public Health
Background:
- Ocular hypertension (OH) and primary open-angle glaucoma (POAG) are significant causes of vision impairment.
- Understanding the economic burden associated with these conditions is crucial for healthcare planning and resource allocation.
Purpose of the Study:
- To determine the total and condition-related direct healthcare charges for patients with OH and POAG.
- To identify key factors influencing these healthcare expenditures.
Main Methods:
- Retrospective cohort study utilizing a large, nationally representative health plan database (PharMetrics).
- Inclusion of 36,767 patients with OH and 72,412 patients with POAG with at least one year of continuous enrollment between 1998-2005.
- Multivariate linear regression models were employed to analyze first-year total and condition-related healthcare charges, adjusting for various covariates.
Main Results:
- Patients with POAG had significantly higher adjusted total ($2070) and condition-related ($556) healthcare charges compared to OH patients ($1990 and $322, respectively).
- Female gender and older age were associated with higher total healthcare charges, but not strongly with condition-related charges.
- Ocular comorbidities such as cataracts, diabetic retinopathy, and blindness substantially increased both total and condition-related healthcare charges (P<0.0001).
Conclusions:
- Healthcare charges for patients with OH and POAG are substantial.
- Factors including the specific ophthalmic condition (POAG vs. OH), patient demographics, treatment, and presence of comorbidities significantly influence healthcare costs.
Objectives:
To determine the total and condition-related direct health care charges of patients with ocular hypertension (OH) or primary open-angle glaucoma (POAG) and identify factors that affect these charges.
Design:
Retrospective cohort study.
Participants:
Patients with OH (n = 36 767) and POAG (n = 72 412) with > or =1 year of continuous enrollment during calendar years 1998 through 2005 in a nationally representative, multimanaged health plan database (PharMetrics).
Methods:
First year total health care and condition-related charges were calculated. Subsequently multivariate linear regression models determined the impact of ophthalmic condition (OH or POAG), age, index year, gender, geographic region, payer mix, product type, treatment with glaucoma medication, ocular comorbidities, and systemic comorbidities on these charges.
Main Outcome Measures:
Per-person per year first-year total health care and ocular condition-related charges in United States dollars, adjusted for multiple covariates.
Results:
Patients with POAG had significantly higher adjusted total and condition-related health care charges during the first year of follow-up than patients with OH in multivariable analysis ($2070 vs. $1990, P<0.0001 and $556 vs. $322 P<0.0001, respectively). Females and older patients had higher total health care charges compared with males and younger patients ($586 or 28.3% more; P<0.0001 and $27 per year or 0.8% per year more; P<0.0001, respectively). However, neither gender nor age were strong determinants of condition-related charges (P = 0.13 and P = 0.052, respectively). Index year, region, payer, and product types significantly dictated both total and disease-related charges. Patients with ocular comorbid conditions, including cataracts, cataract surgery, diabetic retinopathy, and blindness, had significantly higher total and condition-related health care charges than patients without these conditions (P<0.0001).
Conclusion:
Total and condition-related health care charges are considerable for patients with OH and POAG. These data identify several factors that dictate these charges.
Related Concept Videos
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
Glaucoma: Overview
Angle Closure Glaucoma: Treatment
Ophthalmic Drug Delivery Systems
