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[Long-term management of post acute coronary syndrome with oral antiplatelet therapy]

L Lorgis1, M Zeller, J-C Beer

  • 1Service de cardiologie, CHU Bocage, boulevard Mal de Lattre de Tassigny, Dijon, France.

Annales De Cardiologie Et D'Angeiologie
|August 28, 2007
PubMed

Insights

Dual antiplatelet therapy with clopidogrel and aspirin is recommended for acute coronary syndrome (ACS) but remains underused. Real-world data show this underuse negatively impacts patient morbidity and mortality.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Cardiovascular disease is a leading cause of mortality globally.
  • Coagulation inhibitors are crucial in managing acute coronary syndromes (ACS).
  • Dual antiplatelet therapy (DAPT) with clopidogrel and aspirin is the gold standard for ACS management.

Purpose of the Study:

  • To highlight the underutilization of recommended DAPT in ACS.
  • To underscore the negative real-world impact of suboptimal antiplatelet therapy.

Main Methods:

  • Analysis of national and international registries.
  • Review of clinical practice data for ST-elevation and non-ST-elevation ACS.

Main Results:

  • Despite Class I recommendations, DAPT with clopidogrel and aspirin is underprescribed.
  • Failure to prescribe DAPT is associated with increased morbidity and mortality in ACS patients.
  • A significant gap exists between evidence-based guidelines and clinical practice.

Conclusions:

  • The underuse of DAPT in ACS management poses a significant public health challenge.
  • Bridging the gap between randomized trial results and real-world application is critical for improving ACS outcomes.

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