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Related Concept Videos

Somatosensation01:33

Somatosensation

The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
Sensory Perception: Organization of the Somatosensory System01:11

Sensory Perception: Organization of the Somatosensory System

The somatosensory system is the central and peripheral nervous system component that senses and processes touch, pressure, pain, temperature, and body position or proprioception. The process of sensation takes place at three levels:
The receptor level:
The receptor level is the first stage of sensation. It involves the detection of a stimulus by specialized sensory receptors. The stimulus must arrive within the receptor's receptive field. Next, the receptor converts the energy of the stimulus...
What is a Sensory System?01:31

What is a Sensory System?

Sensory systems detect stimuli—such as light and sound waves—and transduce them into neural signals that can be interpreted by the nervous system. In addition to external stimuli detected by the senses, some sensory systems detect internal stimuli—such as the proprioceptors in muscles and tendons that send feedback about limb position.
Overview of Somatic Sensory Pathways01:29

Overview of Somatic Sensory Pathways

Somatic sensory or somatosensory pathways refer to the neural pathways that carry information related to touch, pressure, pain, temperature, and proprioception from the skin, muscles, tendons, and joints to the brain. These pathways involve several stages of processing and integration of sensory information.
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
Introduction to Special Senses01:26

Introduction to Special Senses

Sensory receptors play an integral part in comprehending our external and internal environments. They receive diverse stimuli, converting them into the nervous system's electrochemical signals. This conversion occurs as the stimulus alters the sensory neuron's cell membrane potential, instigating the generation of an action potential. This action potential is subsequently transmitted to the central nervous system (CNS), which integrates with other sensory data or higher cognitive functions.
Sensation01:21

Sensation

Sensory receptors are specialized neurons that respond to specific types of external stimuli, initiating the process known as sensation. This occurs when sensory input, such as light entering the eye, is detected by these receptors, causing chemical changes in the cells of the retina. These cells then convert the sensory stimulus into action potentials that are transmitted to the central nervous system, a process termed transduction.
Absolute thresholds can quantify the sensitivity of sensory...

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Related Experiment Video

Updated: Jul 12, 2026

Structured Motor Rehabilitation After Selective Nerve Transfers
09:34

Structured Motor Rehabilitation After Selective Nerve Transfers

Published on: August 15, 2019

Recent progress in sensory mechanism.

Takashi Suzuki1

  • 1Department of Physiology, Tokyo Dental College, Mihama-ku, Chiba, Japan.

The Bulletin of Tokyo Dental College
|August 28, 2007
PubMed
Summary

This study explores how skin cells, keratinocytes, communicate with sensory neurons to modulate pain signals. Understanding this interaction is key to developing new pain management strategies.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Dermatology

Background:

  • Pain perception involves complex brain processing and sensory neuron activity.
  • Keratinocytes release signaling molecules that influence surrounding cells, including sensory neurons.
  • Direct and indirect communication pathways exist between keratinocytes and sensory neurons.

Purpose of the Study:

  • To investigate the role of keratinocytes in modulating sensory neuron activity related to pain.
  • To elucidate the molecular mechanisms underlying keratinocyte-neuron communication in pain signaling.
  • To explore the relationship between sensory channels and ion channels in pain pathways.

Main Methods:

  • Review of ultrastructural studies on keratinocyte-neuron interactions.

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In-Vivo Calcium Imaging of Sensory Neurons in the Rat Trigeminal Ganglion
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In-Vivo Calcium Imaging of Sensory Neurons in the Rat Trigeminal Ganglion

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  • Analysis of molecular mechanisms of primary sensory neuron activation.
  • Examination of genetic studies on pain-related molecules and ion channels.

    • Main Results:

    • Keratinocytes communicate with sensory neurons via extracellular molecules and membrane apposition.
    • Significant advances have been made in understanding molecular mechanisms of pain detection by sensory neurons.
    • The relationship between sensory neurons and ion channels is increasingly clear.

    Conclusions:

    • Keratinocytes play a role in modulating sensory signaling, contributing to pain perception.
    • Further research into keratinocyte-neuron communication may reveal novel therapeutic targets for pain.
    • Understanding ion channel function is crucial for deciphering pain pathways.