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Effect of antisperm antibodies on computerized semen analysis
J H Check1, H G Adelson, A Bollendorf
1UMDNJ, Robert Wood Johnson Medical School, Cooper Hospital/University Medical Center, Department of OB/GYN, Camden.
Archives of Andrology
|July 1, 1991
Summary
Antisperm antibodies (ASA) negatively impact male fertility. Men with positive ASA showed significantly reduced sperm motility, velocity, and linearity compared to those without antibodies.
Area of Science:
- Reproductive medicine
- Immunology
- Andrology
Background:
- Antisperm antibodies (ASA) are implicated in male infertility.
- Understanding the quantitative impact of ASA on sperm parameters is crucial for diagnosis and treatment.
Purpose of the Study:
- To investigate the correlation between the presence of antisperm antibodies (ASA) and specific semen parameters in a cohort of men.
- To quantify the effect of ASA on sperm motility, velocity, and linearity.
Main Methods:
- Utilized a computerized semen analyzer (CASA) for objective sperm analysis.
- Employed the direct immunobead test (IBT) to detect and assess antisperm antibodies (ASA).
- Analyzed data from 239 men, comparing semen variables between ASA-positive and ASA-negative groups.
Main Results:
- Men with positive antisperm antibody (ASA) results exhibited significantly lower percentages of sperm motility.
- Velocity and linearity of sperm were also significantly reduced in men with detected ASA.
- Computerized semen analysis revealed a clear detrimental effect of ASA on key sperm functional parameters.
Conclusions:
- The presence of antisperm antibodies (ASA) is associated with impaired sperm function in males.
- Objective semen analysis confirms that ASA negatively affects sperm motility, velocity, and linearity.
- These findings underscore the importance of testing for ASA in the etiological investigation of male infertility.