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[Nested case-control study of chrysotile and lung cancer]
Ding-lun Zhou1, Ya-jia Lan, Zhi-ming Wang
1West China School of Public Health, Sichuan University, Chengdu 610041, China.
Objective:
To investigate the relationship between simple exposure to chrysotile and lung cancer.
Methods:
The nested case-control study method was used. All of lung cancer cases collected from a male fixed prospective cohort with follow-up of 30 years served as cases and a 1:4 matched proportion was used to select non-cancer case as controls. Controls matched for sex age (+/-5 years old), work time (+/-5 years) and smoking were collected in the same cohort.
Results:
Forty cases died of lung cancer in the study cohort, and the incidence was higher than the average incidence (SMR =1.77). The top four work types of death density were raw material (741.5), combing and spinning (424.3), weaving (365.0), and repairing (285.5), which was consistent with exposed level. According to the exposed level of chrysotile, the research objects were divided into the high level group and the low level group. The result demonstrated that lung cancer incidence of the high exposed level group of chrysotile was higher (OR = 3.7 95% CI 2.30 approximately 8.16), compared with the low exposed level group.
Conclusion:
Simple exposure to chrysotile can increase the risk of lung cancer for workers who are exposed to chrysotile.