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Updated: Jul 12, 2026

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
Published on: October 5, 2015
[Simultaneous pulmonar, laryngeal and lingual affectation by Mycobacterium tuberculosis]
J A Díaz Manzano1, J L Castillo Romero, M J Padilla Romero
1Servicio de ORL, Hospital La Inmaculada de Huércal-Overa (Almería). jdiazmanzano@hotmail.com
Tuberculosis is increasing in developed nations, with laryngeal and pulmonary sites most common. This case highlights an exceptional instance of simultaneous lingual, laryngeal, and pulmonary tuberculosis in a 39-year-old male.
Area of Science:
- Otorhinolaryngology
- Infectious Diseases
- Pulmonology
Background:
- Tuberculosis (TB) incidence is rising in developed countries.
- Pulmonary TB is most common, followed by laryngeal TB; lingual TB is rare.
- Simultaneous TB affecting the lungs, larynx, and tongue is exceptionally infrequent.
Observation:
- A 39-year-old male presented with bilateral pulmonary TB, left vocal cord TB, and mobile tongue TB.
- Diagnostic tests revealed a negative Mantoux test but a positive sputum culture.
- Acid-alcohol resistant bacilli were identified in lingual and laryngeal biopsies.
Findings:
- The patient received a 6-month course of anti-tuberculosis treatment.
- Following treatment, both laryngeal and lingual lesions resolved completely.
- This represents one of only two reported cases of simultaneous TB in these three locations in the past 30 years.
Implications:
- This case underscores the possibility of rare, multifocal TB presentations.
- Early diagnosis and comprehensive treatment are crucial for resolving extensive TB lesions.
- Further research may elucidate risk factors and optimal management for such unusual TB manifestations.
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