Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thyroid autoimmunity in the current iodine environment.

Labrini Papanastasiou1, Ioannis-Anastasios Vatalas, Demetrios A Koutras

  • 1Endocrine Unit, Evgenidion Hospital, Athens University, Athens, Greece.

Thyroid : Official Journal of the American Thyroid Association
|August 30, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prognostic factors for cardiovascular complications induced by catecholamines in pheochromocytomas and paragangliomas: a systematic review and meta-analysis.

Hormones (Athens, Greece)·2026
Same author

Assessing Physicians' Knowledge, Attitudes, Intentions, Abilities, and Behaviour Toward Physical Activity and Exercise in Non-Communicable Diseases: Questionnaire Development Using an e-Delphi and Cross-Sectional Design.

Healthcare (Basel, Switzerland)·2026
Same author

The Effects of Bariatric Surgery on Female Fertility: A Narrative Review.

International journal of molecular sciences·2026
Same author

Is there an association between hyperandrogenic states in women and endrometrial cancer? A narrative review.

Hormones (Athens, Greece)·2026
Same author

The Intimate Relationship between Adipose Tissue, Fertility, and Bone.

Journal of frailty, sarcopenia and falls·2026
Same author

Comparing the performance of dynamic susceptibility contrast and arterial spin labeling for detecting residual and recurrent glioblastoma with deep learning and multishell diffusion MRI.

Neuro-oncology advances·2026

Increased iodine intake may trigger thyroid autoimmunity by altering thyroglobulin (Tg) antigenicity. While often transient, this effect can persist in some individuals, leading to chronic autoimmune thyroid disease.

Area of Science:

  • Endocrinology
  • Immunology

Background:

  • Iodine is crucial for thyroid hormone synthesis.
  • Iodine deficiency disorders have declined due to prophylaxis and increased intake.
  • Iodine intake's role in human thyroid autoimmunity is debated.

Purpose of the Study:

  • To investigate the controversial role of iodine in inducing or exacerbating thyroid autoimmunity in humans.
  • To explore the mechanisms by which iodine might influence thyroid autoimmune responses.

Main Methods:

  • Review of observational and intervention studies on iodine intake and thyroid autoimmunity.
  • Analysis of antibody patterns against thyroglobulin (Tg) epitopes in relation to iodine exposure.

Main Results:

  • Studies suggest a potential increase in thyroid autoimmune disease incidence with adequate or high iodine intake.

Related Experiment Videos

  • Increased iodine intake may transiently enhance thyroid autoimmunity.
  • Antibody responses vary, with some individuals showing persistent, specific anti-Tg antibodies.

    • Conclusions:

    • Enhanced iodine intake might increase thyroglobulin (Tg) antigenicity, potentially triggering or worsening thyroid autoimmunity.
    • The observed autoimmune exacerbation appears transient in most cases.
    • Persistent autoimmunity may involve specific immunodominant Tg epitopes, possibly influenced by iodine incorporation.