Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

New medications which decrease levothyroxine absorption.

Jennifer John-Kalarickal1, Gwen Pearlman, Harold E Carlson

  • 1Endocrinology Division, Department of Medicine, Stony Brook University School of Medicine, Stony Brook, New York 11794-8154, USA.

Thyroid : Official Journal of the American Thyroid Association
|August 30, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antipsychotic-Related Prolactin Levels and Sexual Dysfunction in Mentally Ill Youth: A 3-Month Cohort Study.

Journal of the American Academy of Child and Adolescent Psychiatry·2023
Same author

Gynaecomastia--pathophysiology, diagnosis and treatment.

Nature reviews. Endocrinology·2014
Same author

Time to recovery in diabetes and comorbidities following Hurricane Katrina.

Disaster medicine and public health preparedness·2012
Same author

Osteoporosis and fracture risk in people with schizophrenia.

Current opinion in psychiatry·2012
Same author

Absorption of levothyroxine when coadministered with various calcium formulations.

Thyroid : official journal of the American Thyroid Association·2011
Same author

Approach to the patient with gynecomastia.

The Journal of clinical endocrinology and metabolism·2011
Same journal

Stimulating Thyrotropin Receptor Antibodies Enhance the Expression of Both Thyrotropin Receptors and Insulin-Like Growth Factor 1 Receptors in Fibroblasts.

Thyroid : official journal of the American Thyroid Association·2026
Same journal

Mild Thyroid Eye Disease-The Most Common yet the Least Studied Presentation of Thyroid Eye Disease.

Thyroid : official journal of the American Thyroid Association·2026
Same journal

In Memoriam: Lawrence Crane Wood (1935-2026).

Thyroid : official journal of the American Thyroid Association·2026
Same journal

Trends in Management and Outcomes of Pediatric Hyperthyroidism Over Two Decades.

Thyroid : official journal of the American Thyroid Association·2026
Same journal

Targeted Therapy-Induced Erythrocytosis in Thyroid Cancers: An Underrecognized Safety Signal from a Retrospective Study.

Thyroid : official journal of the American Thyroid Association·2026
Same journal

<i>Retraction Notice:</i> High Iodine Concentration Attenuates <i>RET/PTC3</i> Oncogene Activation in Thyroid Follicular Cells.

Thyroid : official journal of the American Thyroid Association·2026
See all related articles

Sevelamer hydrochloride and chromium picolinate reduce levothyroxine absorption. Hypothyroid patients should separate these medications from their thyroid hormone replacement therapy by several hours to ensure efficacy.

Area of Science:

  • Pharmacology
  • Endocrinology
  • Gastroenterology

Background:

  • Levothyroxine absorption can be impaired by medications forming insoluble complexes in the gut.
  • Understanding drug-drug interactions is crucial for effective thyroid hormone replacement therapy.

Purpose of the Study:

  • To investigate the acute effects of sevelamer hydrochloride, chromium picolinate, and ezetimibe on levothyroxine absorption.
  • To identify potential interactions impacting thyroid hormone bioavailability.

Main Methods:

  • A study involving seven healthy volunteers assessing levothyroxine sodium absorption.
  • Co-administration of levothyroxine with sevelamer hydrochloride, chromium picolinate, or ezetimibe.
  • Measurement of serum thyroxine levels over a 6-hour period post-ingestion.

Related Experiment Videos

Main Results:

  • Sevelamer hydrochloride significantly reduced the area under the serum thyroxine concentration curve (p < 0.05).
  • Chromium picolinate also significantly decreased serum thyroxine levels (p < 0.05).
  • Ezetimibe demonstrated no significant impact on levothyroxine absorption.

Conclusions:

  • Sevelamer hydrochloride and chromium picolinate interfere with levothyroxine absorption.
  • Patients on thyroid hormone therapy should separate intake of these medications from levothyroxine by several hours.
  • Ezetimibe does not appear to affect levothyroxine bioavailability.