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Resveratrol: from basic science to the clinic
Valeria Cucciolla1, Adriana Borriello, Adriana Oliva
1Department of Biochemistry and Biophysics, F. Cedrangolo, Second University of Naples, Naples, Italy.
Cell Cycle (Georgetown, Tex.)
|August 30, 2007
Summary
Resveratrol, a plant-derived compound, shows anticancer and anti-diabetic potential in preclinical studies. Further clinical research is needed to explore its therapeutic applications, possibly in combination with other drugs.
Area of Science:
- Natural Product Chemistry
- Pharmacology
- Oncology
Background:
- Plants synthesize diverse bioactive natural products.
- Resveratrol (3,5,4'-trihydroxystilbene) is a natural compound with identified anticancer properties.
- Preclinical data suggests resveratrol's antiproliferative and apoptosis-inducing effects against cancer cells.
Purpose of the Study:
- To review the anticancer and metabolic-regulatory effects of resveratrol.
- To highlight the potential of resveratrol in chemotherapeutics and diet-induced metabolic disorders.
- To discuss the limitations and future directions for resveratrol research.
Main Methods:
- Literature review of studies on resveratrol's biological activities.
- Analysis of cellular and animal models investigating anticancer effects.
- Examination of research on resveratrol's impact on diet-induced insulin resistance and hyperglycemia.
Main Results:
- Resveratrol exhibits a pleiotropic mode of action as a carcinogenesis inhibitor.
- Studies confirm resveratrol's chemotherapeutic potential in various cancer models.
- Resveratrol treatment may prevent high-fat diet-induced insulin resistance and hyperglycemia in mice.
Conclusions:
- Resveratrol demonstrates significant potential in cancer treatment and metabolic disease prevention.
- Limited clinical trials exist due to pharmaceutical industry disinterest.
- Resveratrol may be valuable as an adjunct therapy with targeted drugs.
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