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2% hydroxypropyl methylcellulose as a viscous surgical adjunct. A multicenter prospective randomized trial
Journal of Cataract and Refractive Surgery
|November 1, 1991
Summary
This study compared two eye surgery solutions for cataract removal. Both Occucoat and Healon effectively protected the corneal endothelium with no significant difference in cell loss or intraocular pressure.
Area of Science:
- Ophthalmology
- Corneal Science
- Surgical Innovation
Background:
- Cataract surgery, including extracapsular extraction and phacoemulsification, requires protecting the corneal endothelium.
- Viscoelastic agents are crucial for maintaining anterior chamber space and protecting corneal endothelial cells during intraocular procedures.
Purpose of the Study:
- To compare the efficacy of 2% hydroxypropyl methylcellulose (Occucoat) versus sodium hyaluronate (Healon) in protecting corneal endothelial cells.
- To evaluate the impact of these agents on intraocular pressure post-surgery.
Main Methods:
- A multicenter prospective trial involving 222 eyes undergoing cataract surgery.
- Comparison of preoperative and postoperative endothelial cell counts between eyes treated with Occucoat (n=166) and Healon (n=56).
- Measurement of intraocular pressure at 24 hours postoperatively.
Main Results:
- The average endothelial cell loss was 12.1% in the Occucoat group and 10% in the Healon group (P = NS).
- No significant difference was observed in endothelial cell loss between the two groups.
- Intraocular pressure at 24 hours did not differ significantly between the Occucoat and Healon groups.
Conclusions:
- Occucoat is as effective as Healon in protecting the corneal endothelium during cataract surgery.
- Both viscoelastic agents provide comparable safety profiles regarding endothelial cell protection and intraocular pressure management.