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Updated: Jul 12, 2026

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
[The relationship between RSV bronchiolitis and the development of asthma]
Jamal Mahamid1, Michael Armoni, Haim Bibi
1Pediatric Clinic, Kupat Holim Meuhedet and Maccabi Healthcare Services Omm-El-Fahem, Israel.
Insights
Respiratory syncytial virus (RSV) causes infant bronchiolitis and is linked to later asthma. RSV infection may indicate an early predisposition to virus-induced wheezing and lifelong respiratory issues.
Area of Science:
- Pediatric infectious diseases
- Pulmonology
- Epidemiology
Context:
- Respiratory syncytial virus (RSV) is a leading cause of infant bronchiolitis.
- RSV infection in infancy is associated with later respiratory problems, including asthma.
- The precise relationship between RSV and the development of asthma remains unclear.
Purpose:
- To review current data on RSV infection and subsequent respiratory complications.
- To explore the association between RSV and asthma development.
- To discuss RSV bronchiolitis as a potential marker for predisposed respiratory conditions.
Summary:
- RSV is the primary cause of bronchiolitis in infants.
- Infant RSV infection may predict future wheezing and asthma.
- This review examines RSV's role in long-term respiratory health and asthma.
Impact:
- Clarifies the link between early-life RSV and adult asthma.
- Highlights RSV bronchiolitis as a potential early indicator of asthma risk.
- Informs future research on RSV pathogenesis and asthma prevention strategies.
Abstract:
Respiratory syncytial virus (RSV) is the most common cause of bronchiolitis during infancy and is associated with subsequent wheezing and asthma, but the nature of this association is not fully understood. In that sense, RSV bronchiolitis may serve as a marker, reflecting predisposition of the individual for virus-induced wheezing early in life and/ or asthma later in life. This review discusses existing data on RSV infection and respiratory complications later in life, as well as the link between RSV and asthma.
Related Concept Videos
Respiratory Syncytial Virus Disease
Asthma I: Introduction
Asthma-I: Introduction
Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Pulmonary Cycle: Exhalation

