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Updated: Jul 12, 2026
10:52
Radiolabeling and Quantification of Cellular Levels of Phosphoinositides by High Performance Liquid Chromatography-coupled Flow Scintillation
Published on: January 6, 2016
A liquid-scintillation-based primary standardization of 210Pb
Lizbeth Laureano-Pérez1, R Collé, R Fitzgerald
1Physics Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899-8462, USA. lizbeth.laureano-perez@nist.gov
Summary
A new lead-210 (210Pb) radioactivity standard solution has been developed by NIST as SRM 4337. This certified standard ensures accurate radioactivity measurements for researchers and industry professionals.
Area of Science:
- Nuclear Metrology
- Radiochemistry
Background:
- Accurate radioactivity measurements are crucial for various scientific and industrial applications.
- The National Institute of Standards and Technology (NIST) develops and disseminates radioactivity standards to ensure measurement traceability.
Purpose of the Study:
- To develop and certify a new radioactivity solution standard for Lead-210 (210Pb).
- To provide a reliable Standard Reference Material (SRM 4337) for accurate 210Pb activity measurements.
Main Methods:
- Standardization utilized 4πβ liquid scintillation (LS) measurements with CIEMAT/NIST (3H)-standard efficiency tracing (CNET).
- Confirmatory measurements included HPGe gamma-ray spectrometry, 2πα spectrometry for 210Po, and 4πβ(LS)-γ(NaI) anticoincidence counting.
Main Results:
- The new 210Pb solution standard (SRM 4337) is prepared in a nitric acid solution with specified carrier ion concentrations.
- Certified massic activity is (9.037 ± 0.22) kBq g⁻¹ as of June 15, 2006, with uncertainties corresponding to a coverage factor k=2.
Conclusions:
- NIST has successfully developed and certified a new 210Pb solution standard, SRM 4337.
- This standard provides a reliable reference for accurate quantification of 210Pb radioactivity.
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