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Related Concept Videos

In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: Jul 7, 2026

Chromatin Immunoprecipitation Assay for Tissue-specific Genes using Early-stage Mouse Embryos
11:02

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Published on: April 29, 2011

GENOMICS: Rat Genome Off to an Early Start.

E Pennisi

    Science (New York, N.Y.)
    |September 5, 2007
    PubMed
    Summary
    This summary is machine-generated.

    Researchers are accelerating rat genome sequencing efforts. Two mouse genome centers are now prioritizing the rat, bypassing previous funding delays to determine the order of its 3 billion bases.

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    Last Updated: Jul 7, 2026

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    Published on: May 21, 2020

    Area of Science:

    • Genomics
    • Mammalian Genetics

    Background:

    • The rat genome sequencing project was planned but delayed pending funding.
    • The National Human Genome Research Institute (NHGRI) is coordinating genome research.

    Purpose of the Study:

    • To expedite the determination of the rat genome's base order.
    • To leverage existing resources and expertise from the mouse genome sequencing effort.

    Main Methods:

    • Reallocation of resources from mouse genome sequencing centers.
    • Focusing sequencing efforts on the rat genome.

    Main Results:

    • NHGRI has initiated accelerated sequencing of the rat genome.
    • Two sequencing centers previously working on the mouse genome are now involved in rat genome sequencing.

    Conclusions:

    • The rat genome sequencing initiative has commenced ahead of the original schedule.
    • The project benefits from the infrastructure and experience gained from the mouse genome project.