Related Experiment Video

Updated: Jul 12, 2026

Simultaneous Quantification of Anti-vector and Anti-transgene-Specific CD8+ T Cells Via MHC I Tetramer Staining After Vaccination with a Viral Vector
08:10

Simultaneous Quantification of Anti-vector and Anti-transgene-Specific CD8+ T Cells Via MHC I Tetramer Staining After Vaccination with a Viral Vector

Published on: November 28, 2018

Combination vaccine use and vaccination quality in a managed care population

Laura E Happe1, Orsolya E Lunacsek, Gary S Marshall

  • 1Xcenda, Palm Harbor, FL 34685, USA. lhappe@xcenda.com

The American Journal of Managed Care
|September 7, 2007
PubMed

Insights

The pentavalent combination vaccine (diphtheria/tetanus/pertussis/hepatitis B/polio) improved childhood immunization coverage and timeliness. This vaccine led to higher vaccination rates by age two and more on-time vaccinations.

Area of Science:

  • Pediatric Vaccinology
  • Public Health
  • Health Services Research

Background:

  • Childhood immunization is crucial for disease prevention.
  • Managed care organizations face challenges in achieving optimal vaccination coverage and timeliness.
  • The pentavalent vaccine combines multiple antigens into a single injection, potentially simplifying administration.

Purpose of the Study:

  • To assess the impact of the pentavalent combination vaccine (diphtheria/tetanus/pertussis/hepatitis B/polio) on immunization coverage and timeliness.
  • To compare vaccination outcomes between children receiving the combination vaccine and those receiving individual vaccines.

Main Methods:

  • Retrospective matched-cohort analysis using administrative claims and immunization registry data.
  • Two demographically matched cohorts were created: one receiving the DTaP/HepB/IPV combination vaccine and a reference cohort.
  • Vaccination coverage and timeliness were assessed up to 24 months of age for the HEDIS Combination 2 series and individual vaccines.

Main Results:

  • Children receiving the pentavalent combination vaccine showed significantly higher complete vaccination coverage for the HEDIS Combination 2 series by age two (86.9% vs. 74.1%).
  • The combination vaccine cohort also demonstrated improved on-time vaccination rates (45.2% vs. 37.5%).
  • These improvements were statistically significant (P <.001 for coverage, P = .001 for timeliness).

Conclusions:

  • The DTaP/HepB/IPV pentavalent combination vaccine is associated with enhanced immunization coverage and age-appropriate vaccination schedules.
  • Implementation of combination vaccines can be an effective strategy to improve childhood immunization rates in managed care settings.
Abstract

More Related Videos

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

Homogeneous Glycoconjugate Produced by Combined Unnatural Amino Acid Incorporation and Click-Chemistry for Vaccine Purposes13:53

Homogeneous Glycoconjugate Produced by Combined Unnatural Amino Acid Incorporation and Click-Chemistry for Vaccine Purposes

Published on: December 19, 2020

Related Concept Videos

Smallpox01:24

Smallpox

Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.
Vaccinations01:51

Vaccinations

Overview
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...
Preventive Healthcare Services01:30

Preventive Healthcare Services

Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
Methods Of Healthcare Delivery System01:26

Methods Of Healthcare Delivery System

At the different levels of the healthcare system, we see varying methods of healthcare used. These methods include managed care systems, case management, and primary healthcare.
Managed Care System:
The managed care system is designed to control the cost while maintaining the quality of care. The patient's care from admission to discharge is planned by the primary care provider or the case manager, also known as the gatekeeper. In a managed care system, the number of care providers is limited...