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Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
Published on: November 27, 2016
Composition of bile acids in ruminants
G M Sheriha1, G R Waller, T Chan
1Department of Biochemistry, Agricultural Experiment Station, Oklahoma State University, Stillwater, Oklahoma.
Lipids
|January 1, 1968
Summary
Bile acid composition in sheep and beef varied with diet. Purified diets increased specific keto-bile acids, while natural diets favored deoxycholic acid formation from cholic acid.
Area of Science:
- Comparative biochemistry
- Animal physiology
- Organic chemistry
Background:
- Bile acids are crucial for digestion and metabolism.
- Understanding bile acid profiles in different species and diets is important for nutritional and physiological studies.
- Sheep and beef bile acid composition has not been extensively characterized, especially concerning dietary influences.
Purpose of the Study:
- To analyze and compare bile acids in sheep and beef.
- To investigate the impact of natural versus purified diets on bile acid profiles.
- To examine bile acid differences between adult and fetal animals.
Main Methods:
- Conventional analytical techniques were employed for bile acid analysis.
- Animals were maintained on both natural and purified diets.
- Samples analyzed included bile and feces from sheep and beef, as well as fetal samples.
Main Results:
- Cholic acid was the predominant bile acid in both species.
- Deoxycholic acid was the major metabolite of cholic acid on natural diets.
- A high-concentrated purified diet increased 3alpha, 12alpha-dihydroxy-7-keto-5beta-cholanoic acid.
- Fetal bile contained similar bile acids to adults but in different concentrations.
Conclusions:
- Diet significantly influences bile acid composition in sheep and beef.
- Specific bile acids are biomarkers for dietary intake (natural vs. purified).
- Fetal bile acid profiles reflect developmental or physiological differences.
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