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[Synthesis and pharmacological study of alpha-phenyl-1-adamantanemethanamine]
P Marakos1, G B Foscolos, G Fytas
1Laboratoire de Chimie Pharmaceutique, Université d'Athènes, Grèce.
Annales Pharmaceutiques Francaises
|January 1, 1991
Abstract:
The alpha-phenyl-1-adamantanemethanamine 2 was synthesized and its pharmacological action was studied on mice. The behavior effects obtained with this compound (at low dose) as well as the antagonism of the convulsions and the lethality (induced by the amine 2 at high dose) by desimipramine, N-linoleylGABA or N-linoleylglycine, could suggest the existence of glutamatergic (NMDA), anti-GABAergic and antiglycinergic components in the action mechanism of this adamantanamine.