Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Migration cues induce chromatin alterations.

Gabi Gerlitz1, Idit Livnat, Carmit Ziv

  • 1The Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel.

Traffic (Copenhagen, Denmark)
|September 8, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Regulatory adaptation of an accessory gene controls fungal halotolerance and niche expansion.

The ISME journal·2026
Same author

Acute COPD Exacerbation and long-term cardiopulmonary outcomes: Real-world EXACOS-CP evidence study in Israel.

Respiratory medicine·2026
Same author

Impact of milk consumption patterns on cow's milk sensitization and allergy in at-risk children.

The World Allergy Organization journal·2026
Same author

Phenogenomics reveals the ecology and evolution of Trichoderma fungi for sustainable agriculture.

Nature microbiology·2026
Same author

Changes over time in treatment patterns and health care resource utilization in patients with COPD: Real-World data from a large health maintenance organization.

Respiratory medicine·2026
Same author

ERM proteins support perinuclear actin rim formation.

Frontiers in cell and developmental biology·2026
Same journal

The Power of Nup85: Controlling Molecular Traffic and Cellular Fate.

Traffic (Copenhagen, Denmark)·2026
Same journal

Traffic Light Commentary-Src in the Upside Down: A Kinase Turned Inside Out.

Traffic (Copenhagen, Denmark)·2026
Same journal

Integrating Lateral Super-Resolution and Axial Progression Reveals Distinct Clathrin Pit Formation Pathways.

Traffic (Copenhagen, Denmark)·2026
Same journal

A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies.

Traffic (Copenhagen, Denmark)·2026
Same journal

Mechanistic Insight Into Clathrin-Mediated Endocytosis in Plants.

Traffic (Copenhagen, Denmark)·2026
Same journal

Clathrin-Mediated Endocytosis in Plants: Historical to Modern Advances.

Traffic (Copenhagen, Denmark)·2026
See all related articles

Directed cell migration involves chromatin fiber changes. Histone H1 modifications and heterochromatin markers shift during cell movement, suggesting dynamic chromatin reorganization is an early response.

Area of Science:

  • Cell Biology
  • Epigenetics
  • Molecular Biology

Background:

  • Directed cell migration is fundamental to biological processes like development and wound healing.
  • The role of chromatin structure in dynamic cellular responses, such as migration, is not fully understood.

Purpose of the Study:

  • To investigate the association between directed cell migration and changes in chromatin fiber organization.
  • To identify specific epigenetic modifications and histone dynamics during cell migration.

Main Methods:

  • Utilized a wound healing assay to induce directed cell migration.
  • Analyzed posttranslational modifications and mobility of histone H1 in migrating cells.
  • Assessed levels of heterochromatin markers, specifically histone H3 lysine 9 tri-methylation.

Related Experiment Videos

  • Examined histone H1 dynamics during nuclear motility in *Neurospora crassa*.

    • Main Results:

    • Observed polarized posttranslational changes and decreased mobility of histone H1 in cells migrating towards a wound.
    • Detected elevated levels of the heterochromatin marker histone H3 lysine 9 tri-methylation.
    • Found that altering histone H1's chromatin-binding affinity impacts cell migration rates.
    • Confirmed migration-associated histone H1 changes in the multicellular organism *Neurospora crassa*.

    Conclusions:

    • Directed cell migration is linked to global alterations in the chromatin fiber.
    • Dynamic reorganization of chromatin, particularly involving histone H1, is an early cellular response to migration cues.
    • Epigenetic modifications play a crucial role in regulating cell migration.