Related Experiment Video

Updated: Jul 11, 2026

On-Chip Endothelial Inflammatory Phenotyping
12:43

On-Chip Endothelial Inflammatory Phenotyping

Published on: July 21, 2012

Microsomal triglyceride transfer protein 493-T variant is associated with resistin levels and C-reactive protein

Roberto Gambino1, Simona Bo, Giovanni Musso

  • 1Department of Internal Medicine, University of Torino, 10126 Torino, Italy. roberto.gambino@unito.it

Clinical Biochemistry
|September 11, 2007
PubMed
Abstract

Insights

The rare MTP-493T/T genotype is linked to lower LDL-cholesterol and higher resistin levels. This suggests a connection between MTP gene variants, inflammation, and cholesterol in coronary heart disease risk.

Area of Science:

  • Genetics and Molecular Biology
  • Cardiovascular Disease Research
  • Metabolic Syndrome Studies

Background:

  • Microsomal triglyceride transfer protein (MTP) facilitates lipoprotein assembly and secretion.
  • MTP gene polymorphisms, particularly the T variant, correlate with reduced LDL-cholesterol and increased coronary heart disease (CHD) risk.
  • The study investigates the association between MTP gene polymorphism and LDL-cholesterol levels, along with proinflammatory cytokines like resistin.

Purpose of the Study:

  • To examine the relationship between the -493G/T MTP gene polymorphism and LDL-cholesterol levels.
  • To investigate the association between MTP gene polymorphism and serum resistin levels.
  • To explore the link between MTP genotype, LDL-cholesterol, and inflammatory markers such as hs-CRP.

Main Methods:

  • Investigated the -493G/T MTP gene polymorphism in 290 subjects.
  • Compared LDL-cholesterol and serum resistin levels between TT genotype carriers and those with the G allele.
  • Utilized multiple regression analysis, adjusting for age, BMI, waist circumference, alcohol intake, and exercise.

Main Results:

  • Subjects with the TT genotype exhibited lower LDL-cholesterol levels and higher serum resistin levels compared to individuals with the G allele.
  • A significant direct association was found between high-sensitivity C-reactive protein (hs-CRP) and resistin levels in the presence of the TT genotype, even after adjustments.
  • The TT genotype was independently associated with elevated inflammatory parameters and reduced LDL-cholesterol.

Conclusions:

  • The rare MTP-493T/T genotype is associated with elevated inflammatory markers and decreased LDL-cholesterol levels.
  • Further prospective studies are required to determine if the observed association between the MTP-493T/T genotype and cardiovascular disease (CVD) is mediated by an increased subclinical proinflammatory state.

Related Concept Videos

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...