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The use of ductal lavage as a screening tool in women at high risk for developing breast carcinoma
Catherine D Carruthers1, Lori A Chapleskie, Mary Beth Flynn
1The Comprehensive Breast Center at Bryn Mawr Hospital, 101 S. Bryn Mawr Ave, Bryn Mawr, PA 19010, USA. carrutherscatherine@hotmail.com
Background:
The purpose of the study was to determine if ductal lavage could predict the occurrence of breast cancer as well as further stratify patients at high-risk for developing breast cancer.
Methods:
Ductal lavage was performed in 116 high-risk patients (Gail Risk score > or = 1.7%, previous breast cancer, strong family history, previous suspicious biopsy specimen). If atypia or papillary cells were identified, a standard protocol of evaluation was initiated.
Results:
Two hundred twenty-three lavages were performed on 116 patients. Twenty-seven lavages in 25 patients yielded atypical or papillary-like cells. The 15 patients who underwent further evaluation for atypia had no evidence of cancerous or precancerous lesions. All patients were followed-up: 2 developed breast cancer, both of whom had had normal previous lavage. No patient with abnormal lavage developed cancer during follow-up.
Conclusions:
We find ductal lavage to be of limited value in the screening of high-risk patients and have removed it from our treatment algorithm.
