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Multiple cutaneous ganglioneuromas in a dog
K Hermeyer1, M Kühn, K Kuchelmeister
1Department of Pathology, University of Veterinary Medicine Hannover, Buenteweg 17, 30559 Hannover, Germany.
Veterinary Dermatology
|September 12, 2007
Summary
Multiple cutaneous ganglioneuromas, a rare skin tumor in dogs, were identified in a Labrador retriever. These canine tumors share key features with human ganglioneuromas.
Area of Science:
- Veterinary Pathology
- Canine Oncology
- Dermatopathology
Background:
- A 3-year-old Labrador retriever presented with multiple small skin nodules.
- Initial examinations ruled out internal or endocrine tumors.
Observation:
- Cutaneous nodules were located on the thoracic wall, flank, and scrotum.
- Histological analysis revealed two distinct neoplastic cell types within the nodules.
- Mild inflammation was present.
Findings:
- One cell population resembled mature ganglion cells; the other consisted of small, spindle-shaped cells.
- Both cell types expressed vimentin, neurofilament protein, pan-neuronal neurofilament, amyloid-precursor protein, and chromogranin A.
- Spindle cells were also positive for 2', 3'-cyclicnucleotide 3'-phosphodiesterase.
Implications:
- The histological and immunohistochemical findings align with human primary cutaneous ganglioneuromas.
- This case supports the classification of these canine tumors as multiple cutaneous ganglioneuromas.
- Contributes to understanding rare canine skin neoplasms.
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