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Updated: Jul 11, 2026
Subtype-selective Electroporation of Cortical Interneurons
Published on: August 18, 2014
Co-localization and interaction of DPYSL3 and GAP43 in primary cortical neurons
Renata Kowara1, Michel Ménard, Leslie Brown
1National Research Council, Institute for Biological Sciences, M-54, 1200 Montreal Road, Ottawa, Ont., Canada K1A 0R6. Renata.Kowara@nrc-cnrc.gc.ca
Abstract:
Dihydropyrimidinase-like 3 (DPYSL3) and GAP43 are both involved in neurite outgrowth, a crucial process for the differentiation of neurons. The present study shows for the first time that DPYSL3 co-localizes with GAP43 in primary cortical neurons. Further co-immunoprecipitation and overlay assay showed the ability of both recombinant and endogenous DPYSL3 to bind GAP43, indicating a specific interaction between DPYSL3 and GAP43 in primary cortical neurons.
