Related Experiment Video
Updated: Jul 11, 2026
10:39
Using Mouse Mammary Tumor Cells to Teach Core Biology Concepts: A Simple Lab Module
Published on: June 18, 2015
Aromatase inhibitors and tamoxifen: where do we go from here?
Matthew P Goetz1, Charles L Loprinzi
1Mayo Clinic College of Medicine, Rochester, MN 55905, USA. goetz.matthew@mayo.edu
Nature Clinical Practice. Oncology
|September 13, 2007
Abstract
No abstract available in PubMed .
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Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
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