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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
[Altered state of consciousness as a factor affecting the course and consequences of acute viral encephalitis]
Ljiljana Nesić1, Zoran Todorović, Olgica Gajović
1Klinicki centar Kragujevac, Kragujevac.
Introduction:
Acute viral encephalitis is an infectious disease, which is characterized by sudden onset, serious clinical picture and with an uncertain outcome. Disturbances of consciousness are common in the course of acute viral encephalitis. Consciousness is the heighest form of psychic life and consciousness disturbances may include quantitative (somnolentia, sopor, coma) and qualitative symptoms (convulsions, twilight state).
Material And Methods:
We investigated 63 patients with acute viral encephalitis. The youngest patient was 15, and the oldest one 69 years of age. We examined the state of consciousness in all patients.
Results:
Of all examined patients, 54 (85.72%) patients had disturbances of consciousness, 9 (14.25%) patients had no conciousness disturbances, 11 (17.46%) patients had sopor and 24 (38.09%) patients were in coma. The highest percentage of lethal outcomes was recorded in coma patients (12.5%). The longer the duration of consciousness disturbances, the higher the mortality among these patients.
Discussion:
Subjective and objective factors cause different grades and duration of consciousness disturbances. The highest percentage of patients who recovered without consequences was established in the group of patients (81.82%) with somnolence. The highest percentage of patients who recovered with consequences (20.8%) and patients (12.5%) with lethal outcome was recorded in the group of patients in coma. These findings are in correlation with literature data.
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