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Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
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[Farnesoid X receptor (FXR): a novel regulative factor involved in metabolism]

Xiao-Yan Zhang1, You-Fei Guan

  • 1Department of Physiology and Pathophysiology, Peking University Health Science Center, Peking University Diabetes Center, Beijing 100083, China.

Sheng Li Ke Xue Jin Zhan [Progress in Physiology]
|September 22, 2007
PubMed

Insights

Farnesoid X receptor (FXR) regulates bile acid, lipid, and carbohydrate metabolism. Understanding FXR's role offers potential therapeutic strategies for metabolic diseases.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Background:

  • Farnesoid X receptor (FXR) is a nuclear hormone receptor superfamily member.
  • FXR functions as a bile acid receptor.
  • FXR plays a critical role in regulating metabolic processes.

Purpose of the Study:

  • To elucidate the regulatory functions of FXR.
  • To explore the potential of FXR as a therapeutic target for metabolic diseases.

Main Methods:

  • Gene expression analysis.
  • Metabolic pathway studies.
  • Pharmacological investigations.

Main Results:

  • FXR regulates numerous target genes.
  • FXR influences bile acid homeostasis.
  • FXR impacts lipid and carbohydrate metabolism.

Conclusions:

  • FXR is a key regulator of metabolic homeostasis.
  • Targeting FXR may offer novel therapeutic avenues for metabolic disorders.

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