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Assessment of Kidney Function in Mouse Models of Glomerular Disease
Published on: June 30, 2018
IgM nephropathy in adults: incidence and correlation with electron microscopic features
Dipankar Bhowmik1, Arun Chitale, Sushila Bulchand
1Department of Nephrology, Jaslok Hospital and Research Centre, Mumbai. dmbhowmik@rediffmail.com
Indian Journal of Pathology & Microbiology
|September 22, 2007
Summary
IgM nephropathy, a kidney disease, was found in 12.3% of adults with primary glomerular disease. Electron microscopy confirmed deposits in only a third of these cases, suggesting it
Area of Science:
- Nephrology
- Pathology
- Immunology
Background:
- IgM nephropathy is characterized by IgM deposits in glomeruli.
- Diagnosis relies on light microscopy (LM), immunofluorescence (IF), and electron microscopy (EM).
Purpose of the Study:
- To determine the incidence of IgM nephropathy in adults with primary glomerular disease.
- To correlate LM and IF findings with EM features.
Main Methods:
- Renal biopsies from 146 adults with proteinuria and hematuria were analyzed.
- Evaluations included LM, IF, and EM, excluding secondary causes of glomerulonephritis.
Main Results:
- IgM nephropathy was diagnosed in 18 cases (12.3%) of primary glomerular disease.
- Of these, only 6 cases (33.3%) showed characteristic electron-dense deposits on EM.
- IgM deposition was noted in minimal change disease and mesangioproliferative glomerulonephritis.
Conclusions:
- IgM nephropathy may represent a distinct pathological entity in adults.
- EM confirmation of electron-dense deposits is not consistently present in all IgM nephropathy cases.
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