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Updated: Jul 11, 2026

Applications of Spatio-temporal Mapping and Particle Analysis Techniques to Quantify Intracellular Ca2+ Signaling In Situ
Published on: January 7, 2019
Velocity and stability of solitary planar travelling wave solutions of intracellular [Ca]2+
G C Chopra1, B D Sleeman, J Brindley
1Department of Applied Mathematics, University of Leeds, Leeds LS2 9JT, UK. caroline@amsta.leeds.ac.uk
Abstract:
Normal cardiac muscle contraction occurs in response to a rapid rise followed by a slower decay in intracellular calcium concentration. When cardiac muscle cells are loaded with calcium, an intracellular store releases calcium into the cytosol by the process of calcium-induced calcium release (CICR). This release contributes to the rise in intracellular calcium which in turn triggers contraction. We use two qualitative piecewise linear reaction-diffusion models of this behaviour to investigate the speed, stability and waveform of plane waves using singular perturbation techniques.
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