Related Experiment Video
Updated: Jul 11, 2026
06:37
Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke
Published on: July 14, 2023
Higher cortical function deficits among acute stroke patients: The stroke data bank experience
Summary
Higher cortical function deficits are common in acute stroke, with aphasia and neglect being most frequent. These deficits are more prevalent in non-lacunar strokes and can occur without sensorimotor impairment.
Area of Science:
- Neurology
- Neuroscience
- Stroke Medicine
Background:
- Higher cortical function deficits (HCFD) are crucial for diagnosing stroke and assessing neurological impairment.
- Understanding the prevalence and patterns of HCFD in acute stroke is essential for patient management.
Purpose of the Study:
- To determine the frequency and types of HCFD in acute stroke patients.
- To investigate the association between HCFD and stroke etiology and sensorimotor deficits.
Main Methods:
- Utilized the Stroke Data Bank (SDB) prospective database.
- Analyzed 31 defined HCFDs in 1,805 stroke patients examined within 7-10 days of ictus.
- Correlated HCFD with stroke type (cardioembolic, large artery thrombosis, lacunar, undetermined) and sensorimotor signs.
Main Results:
- 641 instances of HCFD were recorded in 422 alert patients.
- Aphasia (41%) and neglect syndrome (27.2%) were the most common HCFDs.
- Cardioembolic infarcts had the highest HCFD association (66%), while lacunar infarcts had the lowest (6%).
- Neglect, apraxia, and anosognosia frequently co-occurred with long tract signs; alexia, aprosodia, and agnosia did not.
- About half of aphasic patients also had sensorimotor impairment.
Conclusions:
- HCFD, particularly aphasia and neglect, are prevalent in acute stroke.
- HCFD are more common in non-lacunar strokes.
- Certain HCFD are less likely to be associated with sensorimotor deficits.
Related Concept Videos
01:15Ischemic Stroke ll: Pathophysiology
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
01:15Ischemic Stroke l: Introduction
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.