Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A mathematical study of simple exponential modelling in biochemical processes.

J Mazumdar1, M Banerjee, L Y Teng

  • 1Department of Applied Mathematics, University of Adelaide, South Australia.

Australasian Physical & Engineering Sciences in Medicine
|December 1, 1991
PubMed
Summary

This study models biochemical transport using exponential functions. The best fit for radio-phosphorus (32P) transport in diabetic rats involved two exponential functions, indicating two key metabolic parameters.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

COVID-19 Stroke Apical Lung Examination Study 2: a national prospective CTA biomarker study of the lung apices, in patients presenting with suspected acute stroke (COVID SALES 2).

NeuroImage. Clinical·2024
Same author

The Effect of Surgical Weight Loss on Cognition in Individuals with Class II/III Obesity.

The journal of nutrition, health & aging·2023
Same author

Potential drug-drug interactions among hospitalised TB patients.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2022
Same author

Nonlocal Reaction-Diffusion Equations in Biomedical Applications.

Acta biotheoretica·2022
Same author

The influence of persistent bleeding after supracervical hysterectomy on depressive and anxious symptoms: a prospective bicenter study.

Archives of gynecology and obstetrics·2022
Same author

The influence of conventional and extended supracervical hysterectomy on sexuality and quality of life parameters: a prospective bi-center study with a special focus on postoperative spotting.

Archives of gynecology and obstetrics·2022

Area of Science:

  • Biochemistry
  • Pharmacokinetics
  • Mathematical Modeling

Background:

  • Complex biochemical processes often require sophisticated analytical models.
  • Transport phenomena in mammalian systems present significant analytical challenges.
  • Exponential functions offer a potential framework for analyzing such processes.

Purpose of the Study:

  • To apply simple exponential functions for analyzing complex biochemical transport.
  • To identify and validate exponential function models using curve fitting techniques.
  • To investigate radio-phosphorus (32P) transport in diabetic rat models.

Main Methods:

  • Analysis of experimental data on 32P transport in insulin-treated diabetic rats.
  • Application of graphical exponential peeling.

Related Experiment Videos

  • Utilization of six iterative computer programs for single and multiple exponential functions.
  • Comparison of exponential peeling with the least squares method.

    • Main Results:

    • The sum of two exponential functions provided the best goodness of fit across computer programs.
    • This two-exponential model suggests two major metabolic parameters govern 32P transport.
    • Identified optimal curve-fitting techniques for biochemical transport analysis.

    Conclusions:

    • Simple exponential functions, particularly the sum of two, effectively model complex biochemical transport.
    • The study provides a robust method for analyzing pharmacokinetic data.
    • Two primary metabolic parameters are crucial for understanding radio-phosphorus transport in this model.