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10:01
Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
Published on: July 10, 2012
Pos-infectious bronchiolitis obliterans in children.
Ana Luísa Lobo1, Micaela Guardiano, Teresa Nunes
1Paediatric Unit, Hospital Padre Américo-Vale do Sousa, Lugar do Tapadinho, 4560-162 Guilhufe Penafiel. analobo@sapo.plt
Revista Portuguesa De Pneumologia
|September 28, 2007
Summary
Bronchiolitis obliterans (BO) in children is often preceded by viral pneumonia. Early diagnosis and supportive care, including nutrition, can improve outcomes for this rare lower airway disease.
Area of Science:
- Pediatric Pulmonology
- Infectious Diseases
- Radiology
Background:
- Bronchiolitis obliterans (BO) is a rare obstructive lung disease in immunocompetent children, typically following lower airway infections.
- Diagnosis traditionally required lung biopsy, but clinical and radiological findings are increasingly used.
Purpose of the Study:
- To review the etiology, clinical presentation, radiological features, treatment, and outcomes of pediatric Bronchiolitis obliterans.
- To identify common initial events and assess the effectiveness of supportive care.
Main Methods:
- Retrospective review of clinical records for 10 pediatric patients diagnosed with BO between January 1997 and December 2002.
- Analysis of patient demographics, preceding infections, clinical symptoms, radiological findings (chest X-ray, CT scan), treatment, and follow-up data.
Main Results:
- Viral pneumonia was the most common preceding event (adenovirus, RSV, parainfluenza).
- Common symptoms included persistent cough/wheezing and failure to thrive (80% of patients).
- Mean age at diagnosis was 16 months; mean follow-up was 36 months. Clinical resolution occurred in 30%, persistent symptoms in 60%, and one patient died from respiratory failure.
Conclusions:
- Bronchiolitis obliterans in children is often post-infectious, with viral pneumonia being a frequent cause.
- Non-invasive diagnosis using clinical and radiological data is feasible.
- Supportive treatment, including nutritional support and oxygen therapy, is crucial for managing pediatric BO and improving patient outcomes.
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