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Published on: November 21, 2025
Origin of renal proximal tubular injuries by Fe(III)-nta chelate
Yuzo Nishida1, Yuuta Ito, Takahiro Satoh
1Department of Chemistry, Faculty of Science, Yamagata University, Yamagata 990-8560, Japan. yuzo@sci.kj.yamagata-u.ac.jp
Abstract:
Interaction between apo-transferrin and several iron(III) chelates has been investigated in terms of the capillary electrophoresis method. Based on the results, it has been clarified that (i) a binuclear iron(III) unit with an oxo-bridge is necessary for the facile transfer of an iron atom from the iron(III) chelate to apo-transferrin, and (ii) the renal proximal tubular injuries by Fe(III)-nitrilotriacetate (Fe-nta) should be due to the unique binuclear structure of this complex, which gives a peroxide adduct of the binuclear Fe-nta in the presence of glutathione cycle and oxygen.
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