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Updated: Jul 11, 2026
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Biological investigation of 131I-labeled new water soluble Ru(II) polypyridyl complex
Kasim Ocakoglu1, Yeliz Yildirim, Fatma Yurt Lambrecht
1Solar Energy Institute, Department of Chemistry, Faculty of Science, Ege University, 35100 Bornova, Izmir, Turkey. kasim.ocakoglu@ege.edu.tr
Abstract:
New [Ru(L1)(dcbpy)(NCS)2] complex was synthesized in a one-pot reaction starting from [RuCl2(p-cymene)]2, where the ligands (dcbpy=4,4'-dicarboxy-2,2'-bipyridine, L1=dipyrido[3,2-a:2',3'-c]phenazine-11-ylcarbonyl)-sodium) are introduced sequentially. The resulting complex was characterized by IR, NMR, and elemental analysis. The complex was labeled with I-131. Biodistribution study of the complex was carried out using 131I-labeled [Ru(L1)(dcbpy)(NCS)2] complex. The biodistribution study performed with albino Wistar male rats has shown that the complex has high uptake in the lung, small intestine, fat, and spleen.
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